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Lab Medicine Highlight: A Case of Hodgkin Lymphoma Mimicking LYG Diagnosed at Autopsy

Mar 09, 2018

Hodgkin lymphoma and lymphomatoid granulomatosis (LYG) are entities that contain a small number of large, variably Epstein-Barr virus (EBV)–positive neoplastic cells scattered within background non-neoplastic mixed inflammatory infiltrate.

The two entities can typically be distinguished histologically by the angiocentric and angiodestructive pattern of lymphomatoid granulomatosis (LYG); also, they differ in overall prognosis. Read about a case of Hodgkin lymphoma in a 64-year-old Caucasian woman, who was diagnosed at autopsy with unusual histologic features and aggressive clinical course that mimicked LYG.

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